Gruppe A
| # | Team | Sp | S | U | N | T/GT | TD | Pkt |
|---|---|---|---|---|---|---|---|---|
| 1 |  Nashville SC | 18 | 12 | 4 | 2 | 35/14 | +21 | 40 |
| 2 |  Inter Miami | 18 | 11 | 5 | 2 | 45/32 | +13 | 38 |
| 3 |  New England | 17 | 9 | 3 | 5 | 28/21 | +7 | 30 |
| 4 |  Chicago Fire | 17 | 9 | 2 | 6 | 32/23 | +9 | 29 |
| 5 |  New York City | 18 | 7 | 5 | 6 | 31/24 | +7 | 26 |
| 6 |  Cincinnati | 18 | 7 | 5 | 6 | 45/44 | +1 | 26 |
| 7 |  Charlotte FC | 18 | 7 | 4 | 7 | 29/27 | +2 | 25 |
| 8 |  New York RB | 18 | 7 | 4 | 7 | 29/39 | -10 | 25 |
| 9 |  DC United | 18 | 5 | 8 | 5 | 26/29 | -3 | 23 |
| 10 |  Orlando City | 18 | 6 | 2 | 10 | 30/47 | -17 | 20 |
| 11 |  Columbus Crew | 18 | 5 | 5 | 8 | 26/28 | -2 | 20 |
| 12 |  Toronto | 18 | 3 | 8 | 7 | 24/32 | -8 | 17 |
| 13 |  Philadelphia Union | 18 | 4 | 4 | 10 | 25/33 | -8 | 16 |
| 14 |  Montreal Impact | 18 | 4 | 4 | 10 | 24/35 | -11 | 16 |
| 15 |  Atlanta United | 18 | 3 | 3 | 12 | 19/33 | -14 | 12 |
Gruppe B
| # | Team | Sp | S | U | N | T/GT | TD | Pkt |
|---|---|---|---|---|---|---|---|---|
| 1 |  Whitecaps | 17 | 10 | 4 | 3 | 38/17 | +21 | 34 |
| 2 |  Los Angeles | 19 | 10 | 4 | 5 | 35/19 | +16 | 34 |
| 3 |  SJ Earthquakes | 18 | 10 | 3 | 5 | 37/24 | +13 | 33 |
| 4 |  Houston Dynamo | 17 | 9 | 2 | 6 | 25/24 | +1 | 29 |
| 5 |  Real Salt Lake | 17 | 8 | 3 | 6 | 29/25 | +4 | 27 |
| 6 |  Dallas | 18 | 7 | 6 | 5 | 32/25 | +7 | 27 |
| 7 |  St. Louis City | 18 | 7 | 5 | 6 | 24/24 | 0 | 26 |
| 8 |  Portland Timbers | 18 | 7 | 3 | 8 | 33/33 | 0 | 24 |
| 9 |  Seattle Sounders | 17 | 7 | 3 | 7 | 20/22 | -2 | 24 |
| 10 |  Minnesota United | 18 | 6 | 6 | 6 | 20/25 | -5 | 24 |
| 11 |  Colorado Rapids | 18 | 7 | 1 | 10 | 27/25 | +2 | 22 |
| 12 |  LA Galaxy | 19 | 5 | 7 | 7 | 24/29 | -5 | 22 |
| 13 |  San Diego FC | 18 | 5 | 6 | 7 | 32/29 | +3 | 21 |
| 14 |  Austin FC | 18 | 4 | 5 | 9 | 22/36 | -14 | 17 |
| 15 |  Sporting KC | 18 | 4 | 2 | 12 | 18/46 | -28 | 14 |