Grupo A
| # | Equipo | PJ | G | E | P | GF/GC | DG | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 |  Nashville SC | 14 | 10 | 3 | 1 | 31/11 | +20 | 33 |
| 2 |  Inter Miami | 15 | 9 | 4 | 2 | 39/28 | +11 | 31 |
| 3 |  Chicago Fire | 14 | 8 | 2 | 4 | 27/16 | +11 | 26 |
| 4 |  New England Revolution | 14 | 8 | 1 | 5 | 22/18 | +4 | 25 |
| 5 |  New York RB | 15 | 6 | 4 | 5 | 25/32 | -7 | 22 |
| 6 |  Charlotte FC | 15 | 6 | 3 | 6 | 24/23 | +1 | 21 |
| 7 |  Cincinnati | 15 | 5 | 5 | 5 | 36/37 | -1 | 20 |
| 8 |  New York City | 15 | 5 | 4 | 6 | 25/21 | +4 | 19 |
| 9 |  DC United | 15 | 4 | 6 | 5 | 21/25 | -4 | 18 |
| 10 |  Columbus Crew | 15 | 4 | 4 | 7 | 21/23 | -2 | 16 |
| 11 |  Montreal Impact | 14 | 4 | 2 | 8 | 22/31 | -9 | 14 |
| 12 |  Orlando City | 15 | 4 | 2 | 9 | 23/44 | -21 | 14 |
| 13 |  Toronto | 14 | 3 | 5 | 6 | 22/29 | -7 | 14 |
| 14 |  Atlanta United | 14 | 3 | 2 | 9 | 14/23 | -9 | 11 |
| 15 |  Philadelphia Union | 15 | 1 | 4 | 10 | 18/30 | -12 | 7 |
Grupo B
| # | Equipo | PJ | G | E | P | GF/GC | DG | Pts |
|---|---|---|---|---|---|---|---|---|
| 1 |  Vancouver Whitecaps | 14 | 10 | 2 | 2 | 34/12 | +22 | 32 |
| 2 |  San Jose Earthquakes | 15 | 10 | 2 | 3 | 34/15 | +19 | 32 |
| 3 |  Real Salt Lake | 14 | 8 | 2 | 4 | 26/19 | +7 | 26 |
| 4 |  FC Dallas | 15 | 7 | 4 | 4 | 30/22 | +8 | 25 |
| 5 |  Los Angeles | 15 | 7 | 3 | 5 | 24/17 | +7 | 24 |
| 6 |  Seattle Sounders | 13 | 7 | 3 | 3 | 17/11 | +6 | 24 |
| 7 |  Houston Dynamo | 14 | 7 | 1 | 6 | 19/23 | -4 | 22 |
| 8 |  Minnesota United | 15 | 6 | 4 | 5 | 18/22 | -4 | 22 |
| 9 |  LA Galaxy | 15 | 5 | 5 | 5 | 22/22 | 0 | 20 |
| 10 |  San Diego FC | 15 | 4 | 5 | 6 | 30/27 | +3 | 17 |
| 11 |  Colorado Rapids | 15 | 5 | 1 | 9 | 25/24 | +1 | 16 |
| 12 |  St. Louis City | 14 | 4 | 4 | 6 | 16/20 | -4 | 16 |
| 13 |  Portland Timbers | 14 | 4 | 2 | 8 | 22/28 | -6 | 14 |
| 14 |  Austin FC | 15 | 3 | 5 | 7 | 19/31 | -12 | 14 |
| 15 |  Kansas City | 14 | 3 | 2 | 9 | 14/36 | -22 | 11 |