In the second matchday of the 2026/27 UEFA Champions League group stage, Manchester United suffered a 0-2 defeat to Atlético Madrid. Across their last 12 Champions League encounters against La Liga sides, Manchester United's record stands at 2 wins, 4 draws, and 6 losses.

Including the Round of 16 in the 2021/22 Champions League, Manchester United's record against Atlético Madrid stands at 1 draw and 2 losses across 3 matches.

In the quarterfinals of the 2018/19 Champions League, Manchester United were eliminated by Barcelona, losing both legs. In the Round of 16 of the 2017/18 Champions League, Manchester United were knocked out by Sevilla with a record of 1 draw and 1 loss. In the 2017/18 Champions League group stage, Manchester United recorded 1 draw and 1 loss against Valencia. In the 2013/14 Champions League group stage, Manchester United also drew 0-0 with Real Sociedad.

Only in the 2021/22 Champions League group stage did Manchester United secure two victories against Villarreal, winning 2-1 and 2-0. Ronaldo scored the decisive goal in the first leg, while Ronaldo and Sancho scored in the second leg.

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